WebO09.893 is a billable ICD-10 code used to specify a medical diagnosis of supervision of other high risk pregnancies, third trimester. The code is valid during the fiscal year 2024 … WebCCT007093 is a small-molecule chemical inhibitor of PPM1D with IC50 value of 8.4μM [1].CCT007093 is a thienylidene cyclopentanone and shows a potent inhibition of …
CCT007093 (CAS 176957-55-4) - Cayman Chem
WebCCT007093 is supplied as a crystalline solid. A stock solution may be made by dissolving the CCT007093 in the solvent of choice, which should be purged with an inert gas. CCT007093 is soluble in organic solvents such as DMSO and dimethyl formamide (DMF). The solubility of CCT007093 in these solvents is approximately 1 mg/ml. WebAug 13, 2007 · The more selective compound, CCT007093, induced P38 phosphorylation at 4 h post-exposure in MCF-7 cells (sensitive to PPM1D inhibition), rising to a peak at 8 h and then decreasing to basal levels ... race entries for strawman
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WebCCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM. JavaScript seems to be disabled in your browser. You must have JavaScript enabled in your browser to utilize … WebApr 24, 2024 · In addition, CCT007093 was shown to suppress cell proliferation regardless of the presence of WIP1 in U2OS cells confirming an off-target effect of the inhibitor . Further, treatment of cells with CCT007093 did not affect levels of p53-pS15 and γH2AX, both well-established substrates of WIP1 . These data suggest that CCT007093 does not … Web(Rayter et al, 2008). CCT007093 exhibited selectivity for PPM1D compared to the most closely related PPM1A phosphatase. This is another example of exploiting oncogene addiction, in this case dependence on PPM1D, with inhibition of its function causing death specifically in those cancer cells that amplify, overexpress and are addicted to it . race engine tools