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Epha2 phosphorylation

WebWe show that the ephrin receptor tyrosine kinase A2 (EphA2) is a cellular receptor for KSHV gH-gL. EphA2 co-precipitated with both gH-gL and KSHV virions. Infection of human epithelial cells with a GFP-expressing recombinant KSHV strain, as measured by FACS analysis, was increased upon overexpression of EphA2. WebJul 1, 2009 · EphA2 is a representative member of a 16 member superfamily of receptor tyrosine kinases (RTK). The corresponding ligands for Eph RTKs, called ephrins, are anchored on the plasma membrane through either a glycophosphatidylinositol linkage (ephrin-A) or through a transmembrane domain (ephrin-B).

Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase …

WebSep 1, 2024 · The EphA2 receptor tyrosine kinase signals through two distinct mechanisms, one regulated by tyrosine phosphorylation and the other by serine/threonine phosphorylation. Serine 892 (S892) is one of the major serine/threonine phosphorylation sites in EphA2, but little is known about its regulation and function. WebEphA2, a member of the Eph receptor tyrosine kinases, is frequently overexpressed in a variety of malignancies, including glioblastoma, and its expression is correlated with poor prognosis. EphA2 acts as a tumor promoter through a ligand ephrin-independent mechanism, which requires phosphorylation o … trendy you https://skyinteriorsllc.com

Oncogenic functions and therapeutic targeting of EphA2 in

WebProgranulin evoked Akt- and Erk1/2-mediated EphA2 phosphorylation at Ser897, which could drive bladder tumorigenesis. We discovered that EphA2 depletion severely blunted progranulin-dependent motility and anchorage-independent growth, and sensitized bladder cancer cells to cisplatin treatment. WebAug 27, 2024 · EphA2 is an important oncogenic protein and emerging drug target, but the oncogenic role and mechanism of ligand-independent phosphorylation of EphA2 at … WebJan 22, 2024 · It has been known that EphA2 is phosphorylated at Tyr588, which is triggered by the ligand binding, and at Ser897 downstream of growth factor signaling. Upon mitotic entry, EphA2 is phosphorylated at Ser897, accompanied by a reduction in Tyr588 phosphorylation. trendy yellow wallpaper

Phosphorylation of EphA2 receptor and vasculogenic mimicry is …

Category:Oncogenic functions and therapeutic targeting of EphA2 …

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Epha2 phosphorylation

Ligand-independent EphA2 contributes to - ProQuest

WebEphA2 can be phosphorylated on S897 by the RSK, AKT and PKA kinases to promote a non-canonical form of signaling that plays an important role in cancer … WebDec 2, 2024 · Surprisingly, EphA2 S897E, with mutation of the functionally best characterized linker phosphorylation site, shows the weakest HDX differences in these regions (Fig. 5e), suggesting that ...

Epha2 phosphorylation

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WebAug 18, 2024 · Under normal conditions, cell–cell contacts allow EphA2 to interact with ephrin A1, which induces EphA2 phosphorylation and activates its downstream signaling. Tyrosine phosphorylation of EphA2 promotes the generation of a complex … WebApr 12, 2024 · EphA2 phosphorylation was significantly increased by DNA trimers carrying three SWL peptides compared to monovalent SWL. In comparison to one of EphA2’s natural ligands ephrin-A1, which is known ...

Web[目的]探讨EphA2在结直肠癌细胞中的生物学功能及其信号调控机制.[方法]qRT-PCR法检测EphA2在结直肠癌细胞系中的表达情况,筛选得到表达量较高细胞株系,利用siRNA沉默该细胞系中EphA2的表达,利用MTT、Transwell、Western blot、qRT-PCR法检测细胞生物学功能变 … WebAug 17, 2024 · Our previous study has demonstrated that fatty acid β-oxidation and oxidative phosphorylation (OXPHOS) in mitochondria is an important energy source for establishment of polarity in hepatocytes, and lipid droplets are likely a crucial endogenous resource in providing fatty acids. ... Hepatocyte EphA2 signaling is important for the …

WebApr 30, 2024 · Depletion of EphA2 promotes inflammasome activation upon infection and aggravates ovalbumin-induced asthma. EphA2 binds to NLRP3 and induces its phosphorylation, thereby blocking inflammasome assembly and activation. Conflict of interest The authors declare that they have no conflict of interest. References

WebIt has been known that EphA2 is phosphorylated at Tyr588, which is triggered by the ligand binding, and at Ser897 downstream of growth factor signaling. Upon mitotic …

WebJul 12, 2024 · Although EPHA2 can inhibit tumorigenesis in a ligand-dependent fashion via phosphorylation of Y588 and Y772, it can promote tumorigenesis in a ligand-independent manner via phosphorylation of S897. temps in west palm beach flWebNov 3, 2024 · EphA2 interacts with PLCγ1 and the kinase activity of EphA2 was required for phosphorylation of PLCγ1. In human lung cancer cells, genetic or pharmacologic inhibition of EphA2 decreased phosphorylation of PLCγ1 and loss of … trendy yet classyWebNov 6, 2024 · EphA2 phosphorylation was significantly increased by DNA trimers carrying three SWL peptides compared to monovalent SWL. In comparison to one of EphA2's natural ligands ephrin-A1, which is known to bind promiscuously to multiple receptors, pinpointed targeting of EphA2 by oligovalent DNA-SWL constructs showed enhanced cell retraction. temps in winsted connecticutWebNov 7, 2013 · Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase Shp2 is a positive regulator for Erk activation downstream of receptor tyrosine kinases for growth factors. It has been controversial how Shp2 induces Erk activation. temps irm cerebralWebApr 6, 2024 · Using western blot, we validated that phosphorylation of JUN at Serine 63 as well as total protein levels of JUN and EPHA2 were reduced upon ponatinib treatment (Supplementary Fig. 8a). temps korrosionsschutzWebDownload scientific diagram Inhibiting EphA2 phosphorylation by ALW-II-41-27 impedes BLBC cell stemness and chemoresistance. (A-B) Detection of sphere formation by mamosphere formation assay ... temps in wichita ksWebJul 30, 2024 · The kinase-dependent functions involve phosphorylation of tyrosine residues in downstream effector proteins. Kinase-independent functions include the ability to act as a scaffold, whereby phosphorylated Tyr, Ser and Thr residues serve as recognition sites for adaptor proteins containing Src homology-2 (SH2) or phosphotyrosine binding … temps in winnipeg man